Two Cases of Hypersexuality Probably Associated with Aripiprazole |
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| Authors: | EunJin Cheon Bon-Hoon Koo Sang Soo Seo Jun-Yeob Lee |
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| Affiliation: | 1.Department of Psychiatry, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.;2.Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.;3.Department of Psychiatry, CHA Gumi Medical Center, CHA University, Gumi, Republic of Korea. |
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| Abstract: | Sexual dysfunction is a common side effect in patients treated with antipsychotics but significant differences exist across different compounds. We report hypersexuality symptoms in two female patients with schizophrenia who were receiving treatment with aripiprazole. The patients experienced more frequent sexual desire and greater sexual preoccupation after taking aripiprazole. We discuss the potential neuro-chemical mechanisms for this and argue that aripiprazole''s unique pharmacological profile, partial agonism with high affinity at dopamine D2-receptor, may have contributed to the development of these symptoms. |
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| Keywords: | Aripiprazole Hypersexuality Dopamine Partial agonist |
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