Systemic lupus erythematosus myocarditis after COVID-19 vaccination |
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| Institution: | 1. Internal Medicine Department, Clínica Universidad de Navarra, Pamplona, Spain;2. Pulmonary Medicine Department, Clínica Universidad de Navarra, Pamplona, Spain;3. Nuclear Medicine Department, Clínica Universidad de Navarra, Pamplona, Spain;4. Department of Cardiology, Clínica Universidad de Navarra, Pamplona, Spain |
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| Abstract: | IntroductionCases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine.ObjectiveDescribe another possible mechanism of myocarditis after COVID-19 vaccination.Case presentationWe describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.Results and discussionSystemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.ConclusionGiven the pathogenic rationales, the association between SLE and myocarditis should be considered. |
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| Keywords: | Systemic lupus erythematosus COVID-19 vaccination BNT162B2 messenger RNA Myocarditis Lupus eritematoso sistémico Vacunación COVID-19 ARN mensajero BNT162B2 Miocarditis |
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