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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
Affiliation:1. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA;2. Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City 545-8585, Japan;3. Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan;4. Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA;5. Division of Hematology-Oncology, Scripps Clinic, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:colorectal cancer  mesenchymal  stroma  aPKC  immunosuppression  immune checkpoint therapy  hyaluronan  inflammation  tumor microenvironment  liver metastasis
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