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CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma
Affiliation:1. Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;2. State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China;3. Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
Abstract:
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Keywords:GBM  oncolytic virus  CAR-T  combination therapy  chemokine  tumor microenvironment
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