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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
Institution:1. Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA;2. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China;3. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China;4. Applied Bioinformatics Laboratories, Office of Science and Research, New York University Grossman School of Medicine, New York, NY, USA;5. Department of Pathology, New York University School of Medicine, New York, NY, USA;6. Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China;7. Department of Biochemistry, Case Western Reserve University and Case Comprehensive Cancer Center, Cleveland, OH, USA;8. Herbert Irving Comprehensive Cancer Center, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA;9. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China;10. Hillman Cancer Center, UPMC, Pittsburgh, PA 15232, USA;11. Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Abstract:
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  • Keywords:lung squamous cell carcinoma  KMT2D  EGFR  ERBB2  SHP2  organoids
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