Oxygenation-sensitive cardiovascular magnetic resonance |
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| Authors: | Matthias G Friedrich Theodoros D Karamitsos |
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| Affiliation: | 1.Montreal Heart Institute, Departments of Cardiology and Radiology, Université de Montréal, Montreal, QC, Canada;2.Departments of Cardiac Sciences and Radiology, University of Calgary, Calgary, Canada;3.Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK |
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| Abstract: | Oxygenation-sensitive cardiovascular magnetic resonance (CMR) is a non-contrast technique that allows the non-invasive assessment of myocardial oxygenation. It capitalizes on the fact that deoxygenated hemoglobin in blood can act as an intrinsic contrast agent, changing proton signals in a fashion that can be imaged to reflect the level of blood oxygenation. Increases in O2 saturation increase the BOLD imaging signal (T2 or T2*), whereas decreases diminish it. This review presents the basic concepts and limitations of the BOLD technique, and summarizes the preclinical and clinical studies in the assessment of myocardial oxygenation with a focus on recent advances. Finally, it provides future directions and a brief look at emerging techniques of this evolving CMR field. |
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| Keywords: | Cardiovascular magnetic resonance Blood-oxygen level-dependent Microcirculation Ischemia Oxygenation |
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