The Effects of Recovery Sleep on Experimental Pain |
| |
| Institution: | 2. RECOVER Injury Research Centre, The University of Queensland, Brisbane, Queensland, Australia;3. National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Queensland, Australia;4. Metro South Addictions and Mental Health Service, Metro South Health Hospital and Health Service, Brisbane, Queensland, Australia;5. National Health and Medical Research Council Centre for Research Excellence – Better Health Outcomes for Compensable Injury, The University of Queensland, Brisbane, Queensland, Australia;2. NHMRC Centre of Research Excellence: Better Health Outcomes for Compensable Injury, The University of Queensland, Herston, Queensland, Australia;3. Tess Cramond Pain & Research Centre, Royal Brisbane & Women''s Hospital, Herston, Queensland, Australia;4. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California;5. Molecular Cancer Epidemiology Laboratory, Population Health Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;6. School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia;11. Transformational Bioinformatics, CSIRO Health & Biosecurity, North Ryde, New South Wales, Australia;12. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia;8. Genetic Epidemiology Laboratory, Mental Health & Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;9. School of Allied Health Science and Practice, The University of Adelaide, Adelaide, South Australia, Australia;2. University of Connecticut School of Medicine, Hartford, Connecticut;3. School of Nursing, Faculty of Health, Dalhousie University, Halifax, Nova Scotia;4. Departments of Psychology and Neuroscience and Pediatrics, Dalhousie University, Halifax, Nova Scotia;5. Centre for Pediatric Pain Research, IWK Health Centre, Halifax, Nova Scotia;6. Georgia State University, Atlanta, Georgia;11. Department of Anesthesia and Pain Management, Sinai Health, Toronto;12. Departments of Comparative Biology and Experimental Medicine, and Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta;8. Lawrence S Bloomberg Faculty of Nursing, University of Toronto;9. Research Institute, The Hospital for Sick Children, Toronto, Ontario;10. Leslie Dan Faculty of Pharmacy, University of Toronto;112. Boston Children''s Hospital, Boston, Massachusetts;123. Harvard Medical School, Boston, Massachusetts;2. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;3. Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;4. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;5. Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, New York;6. Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, Florida;2. Faculty of Psychology and Neuroscience, Experimental Health Psychology, Maastricht, The Netherlands;3. Institute of Neuroscience, division Cognition and Systems, Faculty of Medicine, UCLouvain, Brussels, Belgium |
| |
| Abstract: | Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the restoration of these pain parameters is driven by sleep characteristics of RS. Thus, the present study assessed changes in experimental pain during RS after total sleep deprivation (TSD) to test whether RS parameters predicted the restoration of the pain system. Thirty healthy participants completed one night of habitual sleep, one night of TSD and a subsequent recovery night. At-home sleep during baseline and recovery was assessed using portable polysomnography and a questionnaire. Before and after each night pressure pain thresholds (PPTs), temporal pain summation (TSP) and conditioned pain modulation (CPM) were assessed. PPTs decreased after TSD and increased following RS, indicating a restoration of pain sensitivity after hyperalgesia. RS characteristics did not predict this restoration, suggesting other mechanisms (eg, changes in serotonergic activity) underlying the observed pain changes. TSP indicated a lack of effect of experimental sleep manipulations on excitatory processes whereas CPM lacked sufficient reliability to investigate inhibitory processes. Thus, results indicate moderate effects of sleep manipulations on pain sensitivity, but not on pain modulation.PerspectiveThis article highlights the potential of recovery sleep to let pain thresholds return to normal following their decrease after a night of total sleep deprivation. In contrast, endogenous pain modulation (temporal pain summation, conditioned pain modulation) was not affected by sleep deprivation and recovery sleep. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
