The role of liver sinusoidal endothelial cells in liver remodeling after injury |
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| Affiliation: | 1. Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China;2. Guangdong Key Laboratory of Liver Disease Research, Guangzhou 510630, China;3. Surgical Intensive Care Unit, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China;1. Organ Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao 266100, China;2. Institute of Organ Donation and Transplantation, Department of Medicine, Qingdao University, Qingdao 266100, China;3. Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People''s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;4. National Health Commission (NHC) Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou 310003, China;5. Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China;1. Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China;2. Department of Health Statistics, College of Military Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China |
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| Abstract: | Liver transplantation is the optimal treatment for patients with end-stage liver disease, metabolic liver diseases, and hepatic malignancies that are not amenable to resection. Hepatic ischemia-reperfusion injury (IRI) is the main problem in liver transplantation and liver resection, leading to parenchymal cell injury and organ dysfunction. The damage of liver sinusoidal endothelial cells (LSECs) is a critical event in IRI. LSECs work as an important regulating factor of liver regeneration after partial hepatectomy. This review primarily describes the mechanisms of LSECs injury in IRI and explores the roles of LSECs in liver regeneration, and briefly introduces the protective strategies targeting LSECs damaged in IRI. |
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