The complete microspeciation of arginine and citrulline |
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| Authors: | Orgován Gábor Noszál Béla |
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| Institution: | a Department of Pharmaceutical Chemistry, Semmelweis University, Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Budapest H-1092, Hőgyes Endre u. 9, Hungary |
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| Abstract: | (1)H NMR-pH titrations of arginine, the most basic natural amino acid and citrulline, its neutral counterpart were carried out. Two other closely related auxiliary compounds were also studied. The 8 macroscopic protonation constants were determined. Combining the four datasets in a deductive method, all the 12 microconstants of arginine, the 4 microconstants of citrulline and arginine amide were calculated. An error-propagation analysis and the pH-dependent distribution of the 8 arginine microspecies are provided. |
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| Keywords: | Highly basic media NMR-pH indicator Protonation constant Electrodeless pH determination Metformin |
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