视网膜色素变性光感受器的组织病理学观察

目的：研究视网膜色素变性光感受器的组织病理学改变。方法：对9例11眼视网膜色素变性的光感受器进行光学和电子显微镜观察。结果：发现赤道部光感受器病理损害最明显，其次为周边区、后极部和黄斑。中期病例病理改变包括外节盘膜退变、变小和连接纤毛减少或消失；内节粗短、线粒体肿胀。晚期病例内、外节和纤毛消失，外界膜粘附在色素上皮细胞或Bruch膜上。光感受器细胞核减少、排列紊乱，细胞变性、结构破坏。移位的Müller细胞和增生肥大的细胞突占据了内外节和光感受器细胞核消失所遗留的空间。色素上皮细胞退变，部分消失或移位到视网膜内。结论：视网膜色素变性光感受器有明显损害。（中华眼底病杂志，1996，12：160-162）

HISTOPATHOLOGIC OBSERVATION OF THE PHOTORECEPTORS IN RET1NITISPIGMENTOSA

PURPOSE:Investigating on histopathologic changes of the photoreceptors in retinitis pigmentosa. METHODS:Observation of the photoreceptors of retinitis pigmentosa in 11 eyes among 9 cases using light and electron microscope. RESULTS: The pathologic changes of the photoreceptors were found to be mostly marded at the equatorial area and less at the periphery,posterior pole and macular region of the retina. In relatively early cases,degeneration and shortening of outer segments,reduction or loss of connecting cilia,stubby inner segments and swollen mitochondria Were the predominant findings. In advanced cases,the inner and outer segments and connecting cilia were diminished with reduction of nuclei in number and disarangement,cellular degeneration and disorganization. The outer limiting membrane adhered to RPE or Bruch membrane. The spaces left over by the above pathologicchanges were replaced by the displaced Müller cells and their hypertrophic processes. Also there were degeneration of the RPE cells,and some of them might migrate into the retina. CONCLUSION:Obvious invasions of pathologic processes in photoreceptors of the retina did present in patients with retinitis pigmentosa.（Chin J Ocul Fundus Dis,1996,12:160-162）