| 黄连解毒汤的抗氧化作用研究 |
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| 引用本文： | 黄连解毒汤的抗氧化作用研究[J]. 中国药科大学学报, 2001, (1): 53-55. |
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| 作者姓名： | 王利津 徐强 |
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| 作者单位： | 中国药科大学中药药理教研室， 南京 210038 |
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| 摘 要： | 目的：探讨黄连解毒汤的抗氧化作用。方法：红细胞溶血，肝匀浆MDA生成及羟自由基生成用比色法测定。结果：黄连解毒汤体外给药能明显抑制红细胞自氧化或H2O2，所致红细胞溶血，并抑制小鼠肝匀浆自发性或Fe^2 -Vit C诱发的脂质过氧化反应，对H2O2所产生的羟自由基亦有直接的清除作用。结论：黄连解毒汤对血细胞和组织细胞具有膜保护作用。
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| 关 键 词： | 黄连解毒汤 脂质过氧化 活性氧 抗氧化作用 |
| 文章编号： | 1000-5048(2001)01-0051-03 |
| 修稿时间： | 2000-04-17 |
Anti-oxidative Activity ofHuanglian Jiedu Tang, a Traditional Chinese Recipe |
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| Anti-oxidative Activity ofHuanglian Jiedu Tang, a Traditional Chinese Recipe[J]. Journal of China Pharmaceutical University, 2001, (1): 53-55. |
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| Abstract: | AIM: To examine the antioxidative and hydroxyl radical scavenging activities of Huanglian Jiedu Tang (HJT) %in vitro%. METHODS: The hemolysis of red blood cells, MDA production in liver homogenate and hydroxyl free radical productin were measured by colorimetric assay. RESULTS: The aqueous extracts of HJT exhibited a significant potency in inhibiting murine erythrocyte hemolysis ( P <0.001) and lipid peroxidation in mouse liver homogenate ( P <0.001). The hydroxyl free radical induced by Fenton reaction could be scavenged by HJT. CONCLUSION: These results indicate that HJT has a protective activity for the membranes of erythrocytes and tissue cells. |
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| Keywords: | huanglian Jiedu Tang lipid peroxidation hydroxyl free radical |
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