| 基质金属蛋白酶与肿瘤坏死因子α的检测对化脓性脑膜炎与病毒性脑炎的鉴别意义 |
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| 引用本文： | 王秀霞,于风雪,刘俊英,郭卓平.基质金属蛋白酶与肿瘤坏死因子α的检测对化脓性脑膜炎与病毒性脑炎的鉴别意义[J].脑与神经疾病杂志,2008,16(3):206-207. |
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| 作者姓名： | 王秀霞 于风雪 刘俊英 郭卓平 |
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| 作者单位： | 河北医科大学第二医院儿科,石家庄,050000 |
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| 摘 要： | 目的:探讨脑脊液中基质金属蛋白酶(MMP-2、MMP-9)与肿瘤坏死因子α(TNF-α)的检测在化脓性脑膜炎(化脑)与病毒性脑炎(病脑)患儿早期鉴别诊断中的价值。方法:于入院后48小时(病程5天)内采集脑脊液,TNF-α的测定采用放射免疫法,MMP-2、MMP-9的测定采用双抗体夹心ELISA法。结果:化脑组患儿脑脊液中MMP-2、MMP-9与TNF-α的水平明显高于病脑组与对照组。结论:脑脊液中MMP-2、MMP-9与TNF-α水平的检测可作为化脑和病脑患儿早期鉴别诊断的方法之一。
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| 关 键 词： | 化脓性脑膜炎 病毒性脑炎 基质金属蛋白酶 肿瘤坏死因子-α |
| 文章编号： | 1006-351X(2008)03-0206-03 |
| 修稿时间： | 2007年7月21日 |
Meanings of Detecting Matrix Metalloproteinases and Tumor Necrosis Factor-α for antidiastole between acute Purulent Meningitis and Viral Encephalitis in Children |
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| Institution: | WANG Xiu-xia; YU Feng-xue; LIU Jun-ying; et al Department of Pediatrics; the Second Hospital of Hebei Medical University; Shijiazhuang 050000; China; |
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| Abstract: | Objective:To obtain early antidiastole of acute purulent meningitis(PM)from viral encephalitis(VE)in children through determination of Matrix Metalloproteinases(MMP-2,MMP-9)and Tumor Necrosis Factor-α(TNF-α)level in cerebrospinal fluid(CSF).Methods:The levels of TNF-α in CSF were determined by Radio-immunity,the levels of MMP-2 and MMP-9 in CSF were determined by Enzyme Linked Immunosorbent Assay(ELISA)in 48 hours after hospitalization(in 5 days before onset).Results:The levels of TNF-αand MMP-2,MMP-9 in CS... |
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| Keywords: | Acute purulent meningitis Viral encephalitis matrix Metalloproteinases Tumor necrosis factor-α |
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