BMP复合仿生人工骨填塞犬股骨假体周围髓腔骨缺损的实验研究

目的评估仿生人工骨（PLGA／TCP）材料作为BMP缓释系统载体材料修复犬假体涂层多孔钛周围骨缺损的可行性。方法给予8只犬进行右侧股骨头置换术，并充分扩髓，周围填充BMP复合的PLGA／TCP骨移植材料，应用X线拍片、组织和荧光观察、EDX及SEM检测、骨密度定量分析等方法，观察负重情况下该材料的实际效果。结果术后X线显示，未有出现透亮带、无假体下沉，未见骨质吸收；20周时骨与假体之间紧密接触，多孔钛内骨组织明显长入，以编织骨为主。植入的活性人工骨已经完全降解，骨小梁结构成熟；假体植入肢体与非手术肢体骨密度之比，显示在术后1个月假体植入侧的骨密度值有所降低，而后逐渐升高。结论多孔钛涂层有助于假体内骨与假体的固定，BMP复合PLGA／TCP作为新的骨移植材料应用于关节外科，有广泛的潜力和价值。

PLGA/TCP scaffold with bovine BMP were implanted in femur medullary cavity bone defects peri-prosthesis of Canine

Objective To further evaluate the composite material of bone morphogenetic protein (BMP) and PLGA/TCP for the clinical use of total hip arthroplasty. Methods The PLGA/TCP scaffold was loaded with bovine BMP and then the composites were implanted in 9 femur medullary cavity bone defects around femur prosthesis of canine. Using X-ray, SEM EDX and Bone mineral density means to inspect the effect of BMP loaded PLGA/TCP on peri-prosthesis. Results Canine didn't complicated by aseptic loosening with severe bone loss were included in this study. At 20 weeks point There was new bone formation on the pores of Titanium and bone graft area. BOD shows that bone density of experiment femur are weaker than that of contralateral femur for 1 month after operation. Later numeric value increases step by step. Conclusion The composite of HA coating/porous titanium is promising to increase fixation between prosthesis and bone. At the same time BMP loaded PLGA/TCP as a new kind of bone grafts will be applied widely in clinical orthopedics because of its excellent p, biological properties.