| S-21007,强效5-羟色胺3受体部份激动剂,对小鼠焦虑的作用(英文) |
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| 引用本文： | Philippe DELAGRANGE,René MISSLIN,Thomas W SEALE,Bruno PFEIFFER,Sylvain RAULT,Rierre RENARD. S-21007,强效5-羟色胺3受体部份激动剂,对小鼠焦虑的作用(英文)[J]. Acta pharmacologica Sinica, 1999, 0(9) |
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| 作者姓名： | Philippe DELAGRANGE René MISSLIN Thomas W SEALE Bruno PFEIFFER Sylvain RAULT Rierre RENARD |
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| 作者单位： | Institut de Recherches Internationales Servier，92415 Courbevoie Cdex，France，Laboratoire d'Ethologie et de Neurobiologie-URA CNRS 1295，Universit Louis Pasteur，67000 Strasbourg，France，Department of Pediatrics，University of Oklahoma Health，Oklahoma City OK 73190，USA，Institut de Recherches Internationales Servier，92415 Courbevoie Cdex，France，CERMN，Universit de Caen，14032 Caen Cdex，France，Institut de Recherches Internationales Servier，92415 Courbevoie Cdex，France |
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| 摘 要： | AIM: To study the effect of S-21007, a 5-HT_3partial agonist in different animal models of anxiety inmice. METHODS: S-21007 effects were evaluatedin the behavior tests after intraperitioneal and oral acutetreatment or in the light/dark test after both acute andchronic treatments. RESULTS: S-21007 presentedanxiolytic-like properties after acute administration inthe light/dark box test, the mirrored chamber test, andthe elevated plus-maze at be doses 10 ng·kg~(-1)-100μg·kg~(-1), 1-100 μg·kg~(-1) and 10-100 μg·kg~(-1),respectively. In the light/dark box test, S-21007 wasactive orally after acute treatment at 100 ng·kg~(-1)-10mg·kg~(-1) and after chronic treatment (14 d) at 1-10μg·kg~(-1). S-21007 was devoid of sedative or stimula-
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| 关 键 词： | S-21007 血清素激动药 焦虑 动物行为 迷宫学习 运动活动 探究行为 选择行为 |
Effects of S-21007, a potent 5-HT_3 partial agonist, in mouse anxiety |
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| Philippe DELAGRANGE,Rene MISSLIN,Thomas W SEALE,Bruno PFEIFFER,Sylvain RAULT,Pierre RENARD. Effects of S-21007, a potent 5-HT_3 partial agonist, in mouse anxiety[J]. Acta pharmacologica Sinica, 1999, 0(9) |
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| Authors: | Philippe DELAGRANGE Rene MISSLIN Thomas W SEALE Bruno PFEIFFER Sylvain RAULT Pierre RENARD |
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| Abstract: | |
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| Keywords: | S-21007 serotonin agonists anxiety animal behavior maze learning motor activity exploratory behavior choice behavior |
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