女性下生殖道HPV感染和HPV相关的宫颈肿瘤

子宫颈病变是女性最常见的疾患之一.在女性癌瘤中,宫颈癌的发病率仅次于乳腺癌.人乳头状瘤病毒(HPV)感染在宫颈肿瘤的发病机制中起着重要的作用,许多学者关注HPV疫苗的预防和治疗.在女性生殖道HPV传播及继发性感染是局部性的,因此,针对这种局部性传播疫苗的有效性最好能用局部免疫的参数来评价.

HPV infection and HPV-related cervical neoplasia in the lower female genital tract

Human papillomavirus infections are known to play an important role in the pathogenesis of cervical neoplasia. Many studies focus on the development of both prophylactic and therapeutic HPV vaccines. HPV transmission and subsequent infection is a local event in the lower female genital tract and therefore the efficacy of vaccines against this locally transmitted infection can be assessed by parameters of local immunity. In this review we describe both the epidemiology of HPV related cervical neoplasia and the general aspects of mucosal immunity in the female genital tract while focusing on the local humoral immunity in HPV related cervical neoplasia.