| 半胱天冬酶天然抑制剂与细胞凋亡 |
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| 引用本文： | 孙建义,井明艳. 半胱天冬酶天然抑制剂与细胞凋亡[J]. 中国病理生理杂志, 2005, 21(5): 1036-1040. DOI: 1000-4718 |
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| 作者姓名： | 孙建义 井明艳 |
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| 作者单位： | 浙江大学动物分子营养学教育部重点实验室， 浙江 杭州 310029 |
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| 摘 要： | 在生物体内,细胞增殖与细胞凋亡总是处于动态平衡状态,从而保证了多细胞生物维系其结构稳定和内环境功能平衡及正常生长发育。正常的细胞凋亡可清除体内衰老的、磨损的或已完成功能的细胞,如胚胎细胞、胸腺细胞等;并能清除具有潜在危险的畸变细胞,如自身反应性淋巴细胞、突变细
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| 关 键 词： | 半胱氨酸天冬氨酸蛋白酶 细胞凋亡 |
| 文章编号： | 1000-4718(2005)05-1036-05 |
| 收稿时间： | 2003-09-23 |
| 修稿时间： | 2003-12-15 |
Natural inhibitors of caspases and cell apoptosis |
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| SUN Jian-yi,Jing Ming-yan. Natural inhibitors of caspases and cell apoptosis[J]. Chinese Journal of Pathophysiology, 2005, 21(5): 1036-1040. DOI: 1000-4718 |
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| Authors: | SUN Jian-yi Jing Ming-yan |
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| Affiliation: | The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310029, China |
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| Abstract: | The crucial role of cell death in many diseases is obvious and has intense researches to understand the regulation of apoptotic pathways. Caspase activation is central to many of the apoptotic pathways. In recent years, the research on the regulation and activation of caspase has made a great progress. Caspase inhibitors prevent active caspases from committing the cell to irreversible destruction. This review will mainly focus on the characteristics of natural anticaspase inhibitor-IAP, regulation of IAP expression, mechanisms of action of IAP. |
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| Keywords: | Caspases Apopotosis |
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