The effect of famotidine on neuromuscular transmission. |
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| Authors: | R Bossa M Chiericozzi G Efstathiu I Galatulas M A Ninci |
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| Affiliation: | Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica Emilio Trabucchi, Università di Milano, Italy. |
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| Abstract: | We have investigated the effects of the H2 receptor antagonist famotidine on the neuromuscular transmission by using the sciatic nerve--gastrocnemius muscle preparation of rat in vitro. Famotidine, administered by I.V. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotics. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by famotidine is reversed by 4-aminopyridine but not by dimaprit. Similar results have previously been obtained with cimetidine. |
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