氟脲嘧啶持续静滴联合亚叶酸钙、羟基喜树碱、顺铂治疗晚期胃癌疗效观察

目的 :观察 5 氟脲嘧啶 (5 FU)、亚叶酸钙 (CF)、羟基喜树碱 (HCPT)、顺铂 (DDP)联合治疗IV期胃癌的疗效和耐受性。方法 :5 FU 0 .5g静滴 ,后予 2 .5g/m2 持续输注 4 8h ,CF 30 0mg静注第 0、2 4h ,HCPT10mg/ (m2 ·d)静注d1～5 ,DDP2 0mg/d静滴d1～ 5 ,每 3～ 4周重复。结果 :4 2例Ⅳ期胃癌患者 ,2例完全缓解 ,19例部分缓解 ,总缓解率 5 0 %(2 1/ 4 2 )。主要毒副反应为口腔粘膜炎、腹泻、脱发、恶心呕吐及白细胞减少。结论 :以持续输注 5 FU为主组成的方案治疗Ⅳ期胃癌有一定疗效。毒副反应轻微 ,可以耐受

Clinical Efficacy of 5-FU Continuous Infusion Combined with CF,DDP,and HCPT in Patients with Advanced Gastric Carcinoma

Objective:To evaluate the clinical efficacy and tolerance of CF/5 FU,DDP and HCPT in patients with advanced gastric carcinoma.Methods:A combined chemotherapy scheme of HLEP was used:5 FU 0.5 iv,then 2.5 g/m 2 for 48 hours by continuous infusion,CF 300 mg iv at 0 and 24th hour and HCPT 10 mg/m2/d iv for 5 day as well as DDP 20 mg/d iv for 5 days.The above scheme was repeated every three or four weeks.Results:Of 42 cases of gastric cancer, two had CR and 19 PR,and the response rate(CR+PR) was 50%.The main toxic side effects included stomatitis, diarrhea, alopecia, anorexia,nausea,vomiting and leucopenia.Conclusion:HLFP regimen has a higher response rate in patients with advanced gastric carcinoma.The toxicity is slight and can be well tolerated.