延边地区胃癌中TP和COX-2表达及其临床意义

目的]探讨TP和COX-2在胃癌中的表达及其临床意义。方法]采用免疫组化方法检测TP和COX-2在50例胃癌中的表达,分析其与胃癌临床病理特征及预后的关系。结果]TP和COX-2在胃癌中的阳性表达率分别为56.0%（28/50）和62.0%（31/50）。TP蛋白表达与胃癌的分化程度、浸润深度和淋巴结转移相关（P〈0.05）;COX-2蛋白表达与胃癌淋巴结转移相关（P〈0.05）。胃癌组织中TP和COX-2的表达呈正相关（χ^2=4.565,P〈0.05）。TP表达阳性和阴性者的5年生存率分别为25.0%和54.5%（P〈0.05）;COX-2表达阳性和阴性者的5年生存率分别为22.6%和63.2%（P〈0.05）。结论 ]TP和COX-2在胃癌的发生发展中可能起重要作用,可作为预测胃癌预后的指标。

Expression of TP and COX-2 in Gastric Cancer and Its Significance in Yanbian Region,Jilin Province

Purpose] To investigate the expression of TP and COX-2 in gastric cancer and its clinical significance.Methods] The expression of TP and COX-2 in 50 cases with gastric cancer was detected by immunohistochemistry method. The relationship of TP and COX-2 expression with the clinicopathological features and prognosis were analyzed.Results] The positive rate of TP and COX-2 in gastric cancer was 56.0%（28/50） and 62.0%（31/50） respectively. The expression of TP in gastric cancer tissue related to differentiation,invasion and lymph node metastasis（P〈0.05）. The expression of COX-2 related to lymph node metastasis（P〈0.05）. Positive correlation was found between TP expression and COX-2 expression in gastric cancer tissues（χ^2=4.565,P〈0.05）. The 5 year survival in patients with positive and negative expressions of TP was 25.0% and 54.5%（P〈0.05）,and it in patients with positive and negative expression of COX-2 was 22.6% and 63.2%（P 0.05） respectively.Conclusion] TP and COX-2 might play an important role in carcinogenesis and progress of gastric cancer. Expression of them can be used as prognostic markers for gastric cancer.