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Hemodynamic Drug Interaction: Peridural Lidocaine and Intravenous Ephedrine |
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| Authors: | L. E. Mather Ph.D G. T. Tucker T. M. Murphy M. d'A. Stanton-Hicks J. J. Bonica |
| Affiliation: | Departments of Anesthesiology and Pharmaceutical Sciences, University of Washington School of Medicine, Seattle, Washington;Department of Anesthesiology, University of Massachusetts, Worcester, Massachusetts, U.S.A.;Section of Therapeutics, Academic Division of Medicine, The Royal Infirmary, University of Sheffield, Yorkshire, England |
| Abstract: | Hypotension following peridural anesthesia with lidocaine was treated by intravenous injection of ephedrine. The ephedrine relieved the cardiovascular depression, but was associated with a concomitant increase in plasma lidocaine concentrations. This increase may push the plasma lidocaine concentration into the toxic region. |
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