Ganglioglioma with neurofibrillary tangles (NFTs): neoplastic NFTs share antigenic determinants with NFTs of Alzheimer's disease |
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| Authors: | Dov Soffer Felix Umansky James E Goldman |
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| Institution: | (1) Department of Pathology (Neuropathology), Hadassah Medical Center, P.O. Box 12000, IL-91120 Jerusalem, Israel;(2) Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;(3) Department of Pathology (Neuropathology), College of Physicians and Surgeons of Columbia University, New York, NY, USA |
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| Abstract: | A cerebral ganglioglioma contained abundant neurofibrillary tangles (NFTs) of the paired helical filament (PHF) type. The NFTs in the tumor were argyrophilic and Congo red and thioflavin-S positive. Immunohistochemically, the NFTs were reactive with antibodies to phosphorylated neurofilament protein, PHF/tau and abiquitin. The demonstration in the neoplasm of abnormally phosphorylated and ubiquitinated cytoskeletal components, similar in morphology and in immunoreactivity to those seen in NFTs of Alzheimer's disease, suggest that similar pathogenetic mechanisms may operate in both conditions. |
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| Keywords: | Ganglioglioma Neurofibrillary tangles Paired helical filaments Tau Ubiquitin |
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