Local administration of icariin contributes to peripheral nerve regeneration and functional recovery |
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Authors: | Bo Chen Su-ping Niu Zhi-yong Wang Zhen-wei Wang Jiu-xu Deng Pei-xun Zhang Xiao-feng Yin Na Han Yu-hui Kou Bao-guo Jiang |
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Affiliation: | Bo Chen;Su-ping Niu;Zhi-yong Wang;Zhen-wei Wang;Jiu-xu Deng;Pei-xun Zhang;Xiao-feng Yin;Na Han;Yu-hui Kou;Bao-guo Jiang;Department of Trauma and Orthopedics, Peking University People’s Hospital;Beijing Shijitan Hospital,Capital Medical University;Health Science Center,Peking University; |
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Abstract: | Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local application of icariin after spinal injury can promote peripheral nerve regeneration. |
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Keywords: | nerve regeneration peripheral nerve sciatic nerve traditional Chinese medicine icariin sleeve bridging suture nerve growth factor NSFC grants neural regeneration |
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