左乙拉西坦添加治疗对难治性部分性癫(癎)患者生活质量影响的研究

目的:评价新型抗癫药物左乙拉西坦(Lev)作为添加治疗对难治性部分性癫患者生活质量的影响。方法:43例确诊有癫部分性发作的成年患者随机分为两组:Lev治疗组与安慰剂组,Lev治疗16周后比较两组的有效率和不良反应,并用QOLIE-31量表对两组癫患者进行生活质量评定,所有患者在转入Lev开放性治疗6个月后再次进行QOLIE评估。结果:16周治疗期末Lev组癫部分性发作的治疗有效率明显高于安慰剂组,两组不良反应的发生率相当;Lev组生活质量明显高于安慰剂组,两组患者转入开放性治疗6个月后,生活质量均显著改善。结论:Lev作为添加用药治疗成人难治性部分性癫发作,显著减少发作频率、安全耐受性较好,能够提高癫患者的生活质量。

Effects of Levetiracetam on Quality of Life in Adults with Refractory Epilepsy

Aim:To evaluate the effect of levetiracetam(Lev) as add-on therapy on quality of lif(eQOL) in patients with refractory partial-onset seizures. Methods:43 epileptic adults were randomly divided into two groups:one was treated with Lev,while the other with placebo. The seizure frequency and side effects were compared after 16 weeks of therapy. QOLIE-31 was used to measure the QOL of all patients at the end of 16 weeks of randomized,double-blind study and at the end of 6 months after that patients switched to open label period. Results:Lev significantly decreased the seizure frequency compared with placebo,while the incidences of AEDs were not significantly different between two groups. The QOL was improved in Lev group than in placebo group. Conclusion:Lev as an adjunctive treatment to partial seizure can effectively control seizure frequency and seems to have a positive impact on QOL.