帕金森病患者脑干听觉诱发电位的研究 |
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引用本文: | 王铭维,顾平,李艳敏,郭记宏,孙海民,孟莉. 帕金森病患者脑干听觉诱发电位的研究[J]. 临床神经电生理学杂志, 2009, 18(3): 148-150 |
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作者姓名: | 王铭维 顾平 李艳敏 郭记宏 孙海民 孟莉 |
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作者单位: | 河北医科大学第一医院神经内科,河北石家庄,050031 |
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摘 要: | 目的:探讨帕金森病(PD)患者脑干听觉诱发电位(BAEP)表现及其对PD的诊断意义。方法:PD组患者67例,并选择年龄、性别与之相匹配的30例正常人为正常对照,观察两组BAEP的差异。比较PD患者不同病程、统一帕金森病评定量表(UPDRS)的不同评分、Hoehn—Yahr(H—Y)的不同分期的BAEP的异同。结果:PD患者BAEP总异常率为23.9%,以Ⅰ-Ⅲ波间期(IPL)异常为主。PD组患者Ⅲ波、V波潜伏期(PL)、Ⅰ-ⅢIPL、Ⅲ-ⅤIPL、Ⅰ—ⅤIPL较对照组明显延长,差异具有统计学意义。而在PD组中,病程≥5年的患者Ⅰ—ⅤIPL较病程〈5年的患者明显延长,UPDRS得分≥36分的患者波ⅢPL较UPDRS得分%36分的患者明显延长,差异具有统计学意义。而不同H—Y分期患者BAEP比较,差异无统计学意义。结论:PD患者听觉传导通路存在异常,随着病程延长,UPDRS评分增高,BAEP更容易出现异常。
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关 键 词: | 帕金森病PD) 脑干听觉诱发电位(BAEP) 病程 统一帕金森病评定量表(UPDRS) |
The study of brain stem auditory evoked potential in Parkinson's disease |
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Affiliation: | WANG Mingwei,GU Ping, LI Yanmin, et al( Dept of Neurology, the First Hospital of Hebei Medical University, Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang( 050031) , Hebei China) |
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Abstract: | Objective:To study the brain stem auditory evoked protential(BAEP) of patients with Parkinson's disease(PD) and its assessment of utility in this disease. Methods: BAEP was observed in sixty-seven patients with PD and 30 gender-age matched normal controls and the difference between two groups was recorded. A second comparison was made in different cource,unified Parkinson's disease rating scale(UPDRS),H-Y stages of patients with PD. Results: The abnormality rate of BAEP was 24%. The peak altency(PL) of Wave Ⅲ , Ⅴ and the interpeak latency (IPL) of Ⅰ-Ⅲ ,Ⅲ -Ⅴ and Ⅰ - Ⅴ were significantly prolonged in palients with Parkinson' s disease compared with the control group. Meanwhile the Ⅰ -Ⅴ IPL in a long course(≥5 years) with patients PD was prolonged compared with the short course(〈5 years) group. The Wave Ⅲ PL was prolonged in the higher UPDRS group(≥36) compared with the lower UPDRS group(〈36). Thers is no difference between different H-Y stages. Conclusion: There was abnormality of auditory pathway in patients with PD and the Wave Ⅲ PL, the Ⅰ - Ⅴ IPL were prolonged with a longer course and higher UPDRS scores. |
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Keywords: | Parkinson's disease(PD) Brainstem auditory evoked potential(BAEP) Course Unified Parkinson's disease rating scale(UPDRS) |
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