带神经、血管预构皮瓣的动物实验及临床应用研究

目的探讨带神经、血管的预构皮瓣治疗四肢严重皮肤缺损的可行性.方法动物实验:新西兰大耳白兔15只,随机分为3组各5只.A组:植入腹壁下动静脉血管束;B组:植入阴部外动静脉血管束; C组:植入股动静脉血管束及部分股神经.术后3周观察血管、神经生长情况.临床应用:手背皮肤缺损患者2例,用腹壁下深动脉和股外侧皮神经转移至腹壁皮下预构皮瓣,修复创面.结果动物实验:3组预构皮瓣血管生长良好,C组可见少量神经纤维和轴突向远端生长.临床应用:2例患者皮瓣全部成活良好,且有皮肤浅感觉.结论预制带神经、血管的皮瓣并用于治疗四肢严重皮肤缺损是可行的.

Experimental study of prefabricated flaps on animal model and clinical application on patients

Objective To study the feasibility of the application of the prefabrication flap in the se rious skin defect of extrimites.Methods Animal experiments:15 New Zealand white rabbits were divided into three groups.Group A was implanted the inferior epigastric artery and vein,Group B was the external pedendal artery and vein,Group C was the femoral arte ry,vein and nerve.All the models were observed directly or under microscope.C linical application: Select 2 patient which were injured on the hands.Firstly ,transfered the deep inferior epigastric artery and lateral femoral cutaneous n erve to the subcutaneous of the abdomen,then repaired the wounded area of the d orsum.Results Animal experiments:The blood vessels under the prefabricated flaps survived well.Some nerve fiber and axons were seen growing toward distal end in group C.Clinical application:The flaps of the 2 patients were survived well,and the sensation of the skin were recovered.Co nclusion Prefabricated flaps with vessels and nerves are feasible i n the treatment of the serious skin defect of extrimites.