Computer-aided detection in direct digital full-field mammography: initial results |
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Authors: | F Baum U Fischer S Obenauer E Grabbe |
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Institution: | 1.Department of Radiology, Georg-August-Universit?t G?ttingen, Robert-Koch-Strasse 40, 37075 G?ttingen, Germany, |
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Abstract: | For the first time, full-field digital mammography (FFDM) allows computer-aided detection (CAD) analysis of directly acquired
digital image data. The purpose of this study was to evaluate a CAD system in patients with histologically correlated breast
cancer depicted with FFDM. Sixty-three cases of histologically proven breast cancer detected with FFDM (Senographe 2000D,
GE Medical Systems, Buc, France) were analyzed using a CAD system (Image Checker V2.3, R2 Technology, Los Altos, Calif.).
Fourteen of these malignancies were characterized as microcalcifications, 37 as masses, and 12 as both. The mammographic findings
were categorized as BI-RADS 3 (n=5), BI-RADS 4 (n=17) and BI-RADS 5 (n=40). The sensitivity for malignant lesions and the rate of false-positive marks per image were calculated. The sensitivity
and its 95% confidence interval (CI) were estimated. The sensitivity of the CAD R2 system in breast cancer seen on FFDM was
89% for microcalcifications CI95%=(70%; 98%)] and 81% for masses CI95%=(67%; 91%)]. As expected, the detection rate was higher in lesions categorized as BI-RADS 5 (37 of 40) compared with lesions
categorized as BI-RADS 4 (11 of 17). In the group categorized as BI-RADS 3 the detection rate was 4 of 5 lesions; however,
this group was very small. The rate of false-positive marks was 0.35 microcalcification marks/image and 0.26 mass marks/image.
The overall rate of false-positive marks was 0.61 per image. CAD based on FFDM provides an optimized work flow. Results are
equivalent to the results reported for CAD analysis of secondarily digitized image data. Sensitivity for microcalcifications
is acceptable and for masses is low. The number of false-positive marks per image should be reduced.
Electronic Publication |
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Keywords: | Computer-aided diagnosis Direct digital full-field mammography Microcalcifications BI-RADS classification |
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