牛磺胆酸钠致急性胰腺炎时大鼠胰腺微血流的变化

作者观察了４２只大鼠用不同浓度牛磺胆酸钠诱导的急性出血坏死性胰腺炎时平均动脉压、胰腺微区血流量、血清淀粉酶和脂肪酶和脂肪酶及胰腺病理形态的变化。发现在大鼠胰腺炎早期、平均动脉压尚无明显改变时，胰腺微区血流量降低；且随着诱导剂浓度的增加，血清淀粉酶和脂肪酰进一步高，胰腺病理损害加重，胰腺微血流进一步恶化。表明胰腺炎早期即可出现明显的胰腺微血流障碍，胰腺微血流障碍的程度与胰腺炎时释放入血的胰酶及胰腺炎

Pancreatic Blood Perfusion in Sodium Taurocholate-induced Pancreatitis in Rats

The alternations of mean arterial pressure, pancreatic microflow, serum amylase and lipase, and pancreatic histology were studied in 42 rats in acute necrotizing pancreatitis induced by various concentrations of sodium taurocholate. The results showed that disturbance of pancreatic microflow which was shown by diminished pancreatic microflow asurred dramatically in the early stage of acute pancreatitis(AP) when mean arterial pressure remained stable; as concentration of the inducer increased, levels of serum amylase and lipase increased, pancreatic pathology worsened, and disturbance of pancreatic microflow further evolved. It is suggested that disturbance of pancreatic microflow might occur in the early stage of AP; disturbance of pancreatic microflow might be coincident with the pancreatic enzymes which were directly released into the blood stream during pancreatitis and with the severity of pancreatitis.