幽门螺杆菌感染与反流性食管炎关系的研究

目的探讨幽门螺杆菌（Hp）感染及谷胱甘肽转硫酶P1（GSTPl）基因型多态性表达与反流性食管炎（RE）的关系。方法RE患者119例和正常对照者121例，以快速尿素酶试验及^13C-尿素呼气试验检测Hp感染，通过PCR-RFLP方法检测GSTP1基因型。结果具有GSTP1突变型基因表达、Hp感染阴性者RE发病率显著增加（P〈0．05）。RE患者中GSTP1野生纯合子型基因组Hp感染率显著高于突变型基因组（P〈0．05）。结论GSTP1基因型多态性与RE发病风险相关，RE患者GSTP1基因表达与Hp易感性相关。

A study on the relationship between helicobacter pylori and reflux esophagitis

Objective To study the relationships of Helicobacter pylori(Hp),genetic polymorphisms of glutathione s-transferase P1(GSTP1) and reflux esophagitis(RE).Methods 119 patients with RE and 121 controls were enrolled for this study.Rapid urease test and ~(13)C-rapid urea breath test(~(13)C-UBT) were used to check Hp.PCR-based restriction fragment length polymorphisms(PCR-RFLP) was used to detect GSTP1 genotype.Results The risk of RE would notably increase in the GSTP1 variant gene(GM and MM) group without Hp(P<0.05).In RE group,the rate of Hp infection of GSTP1 wild homozygote group(GG) was notably higher than that of GM and MM group(P<0.05).Conclusion GSTP1 was correlated with RE.In RE group,the GSTP1 gene was associated with susceptibility to the infection of Hp.