HBeAg阴性与阳性慢性乙型肝炎患者临床和病毒学特点分析

目的:回顾性分析HBeAg阴性和HBeAg阳性慢性乙型肝炎(CHB)患者在HBV DNA载量、肝功能及肝脏组织病理学方面的特点。方法:对60例CHB患者的临床资料,包括HBV DNA载量、肝功能及肝组织病理学检查结果进行回顾性分析。结果:60例患者中HBeAg阴性24例,占40.0%(24/60),平均年龄(48.3±7.7)岁;HBeAg阳性36例,占60.0%(36/60),平均年龄(27.7±9.1)岁,两者在平均年龄之间比较,差异有显著性意义(t=13.4,P<0.001)。HBeAg阴性与阳性患者的HBV DNA载量分别为(5.87±0.66)log拷贝/ml和(7.37±0.50)log拷贝/ml,两者之间比较,差异有显著性意义(t=13.6,P<0.001);ALT分别为(115.95±33.6)U/L和(172.2±84.20)U/L,两者之间比较,差异有显著性意义(t=4.81,P<0.001)。HBeAg阴性患者的肝组织炎症活动度分级(G)及纤维化分期(S)与HBeAg阳性者之间比较,差异无统计学意义(χ2值分别为2.53及1.27,P值分别为0.11及0.25)。结论:HBeAg阴性CHB患者的平均年龄高于HBeAg阳性者,HBV DNA载量及ALT值低于HBeAg阳性者,但HBeAg阴性CHB患者的肝脏组织病理学改变与HBeAg阳性者无差异。

Analysis of clinical and virological characteristics between HBeAg-positive and HBeAg-negative patients with chronic hepatitis B

Objective:To retrospectively analyze the characteristics of the HBV DNA loads,liver function and liver histopathology between HBeAg-positive and HBeAg-negative patients with chronic hepatitis B(CHB).Methods:The clinical detection dates of 60 CHB patients,who were hospitalized in our department from May 2010 to October 2010,were analyzed retrospectively,including HBV DNA loads,liver function and liver histopathology.Results:Among 60 CHB patients,24 cases were HBeAg-negative accounting for 40%(24/60),whose average age were(48.3±7.7) yeas old,and 36 cases were HBeAg-positive accounting for 60%(36/60),whose average age were(27.7±9.1) yeas old.There was a significant difference in average age between HBeAg-negative and HBeAg-positive patients with CHB(t=13.4,P<0.001).The HBV DNA loads of HBeAg-negative and HBeAg-positive patients with CHB were(5.87±0.66) log copies/ml and(7.37±0.50) log copies/ml respectively,between which there was a significant difference(t =13.6,P<0.001).The alanine transarninase(ALT) value of HBeAg-negative and HBeAg-positive patients with CHB were(115.95±33.6) U/L and(172.2±84.20) U/L respectively,between which there was a significant difference(t =4.81,P<0.001).There was no statistically significant in inflammation grade(G) and fibrosis stage(S) of liver tissue between HBeAg-negative and HBeAg-positive patients with CHB(the χ2 value were 2.53 and 1.27 respectively;the P value were 0.11 and 0.25 respectively).Conclusion:The average age of HBeAg-negative patients with CHB are higher than HBeAg-positive patients.The levels of ALT and HBV DNA loads in HBeAg-negative patients with CHB are lower than HBeAg-positive patients.However,there is no difference in liver histopathological changes between HBeAg-negative and HBeAg-positive patients with CHB.