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白介素10的基因多态性与尖锐湿疣的相关性研究
引用本文:何超蔓,梁峰冰,胡春霞.白介素10的基因多态性与尖锐湿疣的相关性研究[J].中国优生与遗传杂志,2012(1):16-17,20.
作者姓名:何超蔓  梁峰冰  胡春霞
作者单位:杭州市下沙医院妇产科;浙江大学医学院附属邵逸夫医院妇产科;海南医学院附属医院妇产科
摘    要:目的探讨白介素10(IL-10)基因启动子-1082位点基因多态性与尖锐湿疣的相关性。方法采用焦磷酸测序法(Pyrosequencing)检测30例尖锐湿疣患者(观察组)和50例健康体检者(对照组)IL-10基因启动子-1082G/A位点基因型和等位基因频率;同时采用双抗体夹心ELISA法测定对照组和观察组的血清IL-10水平。结果观察组血清IL-10水平显著高于对照组(P〈0.01)。观察组IL-10基因启动子-1082 G/A位点GG基因型分布频率和G等位基因频率高于对照组(P〈0.01)。在观察组中表达GG基因型患者的血清IL-10水平显著高于表达其它基因型患者的血清IL-10水平(P〈0.05)。结论 IL-10基因多态性与尖锐湿疣易感性可能相关,IL-10基因启动子-1082 G/A位点GG基因型携带者对尖锐湿疣的易感性高。

关 键 词:IL-10  基因多态性  尖锐湿疣  Pyrosequencing

Study on the correlation between the polymorphisms of gene promoter-1082G/A in interleukin 10 and condyloma acuminatum
HE Chao-man,LIANG Feng-bin,HU Chun-xia.Study on the correlation between the polymorphisms of gene promoter-1082G/A in interleukin 10 and condyloma acuminatum[J].Chinese Journal of Birth Health & Heredity,2012(1):16-17,20.
Authors:HE Chao-man  LIANG Feng-bin  HU Chun-xia
Institution:1.Department of Obstetrics and Gynecology,Xiasha Hospital,Hangzhou,310000,China;2.Department of Obstetrics and Gynecology,sir run run Shaw Hospital,Medical College of Zhejiang University,Hangzhou,310016,China;3.Department of Obstetrics and Gynecology,Hainan Hospital,Hainan Medical College,Haikou,570001,China)
Abstract:Objective:To investigate the correlation between the polymorphisms of gene promoter-1082G/A in interleukin 10(IL-10) and condyloma acuminatum.Methods: Pyrosequencing was used to detect the single nucleotide polymorphisms(SNP) of gene promoter-1082G/A in IL-10 of 30 patients with condyloma acuminatum(observing group) and 50 normal controls(control group).ELISA was carried out to detect the serum level of IL-10 of observing group and control group.Results: The IL-10 levels of observing group were higher than that of control group(P<0.05).Frequencies of GG genotype and allele G at position-1082G/A of observing group were significantly higher than that of control group(P<0.01).In the observing group,IL-10 levels of patients expressing GG were higher than that of patients non-expressing GG(P<0.05).Conclusions: The polymorphisms of IL-10 gene may be correlated with condyloma acuminatum.People who carry genotype GG of gene promoter-1082G/A in IL-10 may have susceptibility to condyloma acuminatum.
Keywords:IL-10  Polymorphisms  Condyloma acuminatum  Pyrosequencing
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