高尿酸血症与冠心病及危险因素的相关性分析

目的 通过对高尿酸血症与冠心病及危险因素的横断面研究,分析高尿酸血症与冠心病及危险因素的相关性.方法 入选太原市中心医院心内科符合标准患者150例,依据尿酸水平分为高尿酸血症组(80例)及非高尿酸血症组(70例).记录年龄、性别、身高、体重、腰围、臀围、血压及血生化指标等基本资料,通过横断面研究高尿酸血症与冠心病及危险因素的关系.结果 高尿酸血症组与非高尿酸血症组比较,在吸烟年限、收缩压(SBP)、舒张压(DBP)、腰围、腰臀比、体重指数(BMI)、三酰甘油、总胆固醇、空腹血糖等均有统计学意义(P＜0.05).高尿酸与冠心病间存在相关性.针对高尿酸血症危险因素空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL - C)、BMI以及代谢综合征(MS)四者进行多元Logistic回归分析,并校正年龄、性别、吸烟、饮酒后分析表明,MS(校正前OR=1.110,校正后OR=1.111,P＜0.001)及FBG(校正前OR=2.586,校正后OR=2.685,P＜0.001)是高尿酸血症的独立危险因素,而LDL -C(校正前OR=0.638,校正后OR=0.642,P＜0.05)则是高尿酸血症的保护因素.BMI的Logistic回归分析无统计学意义(校正前OR=0.795,校正后OR=0.757).结论 高尿酸血症与冠心病存在一定的协同作用；在高尿酸血症的危险因素中MS、FBG是高尿酸血症的独立危险因素,LDL -C是高尿酸血症的保护因素.

Relationship between Hyperuricemia,Coronary Heart Disease and Its Risk Factors

Objective To analyze the relationship between hyperuricemia,coronary heart disease and its risk factors.Methods One hundreds and fifty patients(pts) were divided into high uric acid group(n=80) and non-high uric acid group(n=70).The age,sex,height,weight,waist circumference(WC),hip circumference(BP),blood pressure,blood glucose,creatinine,uric acid,total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) and other basic information were recorded and analyzed by cross-sectional study.Results There were significantly difference in years of smoking,systolic BP(SBP),diastolic BP(DBP),WC,waist to hip(WHR),body mass index(BMI),TG,TC,fasting blood glucose(FBG),and creatinine in two groups(P<0.05).Adjusting for age,sex,smoking,and alcohol consumption,FBG,LDL-C,BMI and metabolic syndrome(MS) were analyzed by multivariate logistic regression analysis and showed MSodds ratio(OR)=1.110,adjusted OR=1.111,P<0.001],FBG(OR=2.586,adjusted OR=2.685,P<0.001),and higher serum uric acid were independent risk factor.LDL-C(OR=0.638,adjusted OR=0.642,P<0.05) was a protective factor for hyperuricemia.There was no relation between hyperuricemia and BMI(OR=0.795,adjusted OR=0.757).Conclusion There is certain relation between coronary heart disease and hyperuricemia.MS and FBG is an independent risk factor of hyperuricemia,and LDL-C is a protective factor of hyperuricemia.