益气健脾法治疗原发性干燥综合征的临床观察

目的 观察益气健脾法治疗干燥综合征的临床疗效.方法 40例病例，随机分为治疗组20例，对照组20例.治疗组给予益气健脾汤（黄芪、太子参、白术、北沙参、麦冬、五味子、大白芍、甘草、乌梅、丹参、鸡血藤等）口服.对照组口服泼尼松，疗程为3 mo.结果 治疗组治疗前后Schirmer＇s 试验和含糖试验积分下降，差异有统计学意义（P＜0.05） 治疗组治疗前后中医症状积分下降，差异有高度统计学意义（P＜0.01） 治疗后，治疗组中医症状积分低于对照组，差异有统计学意义（P＜0.05） 治疗组与对照组其治疗前后的实验室指标差异均有统计学意义（P＜0.05） 治疗组中医症候积分改善率为85%，对照组为55%，2组间差异无统计学意义 2组总体疗效分别为80%和65%，2组间差异无统计学意义.结论 以益气健脾法为主，配合滋阴润燥、养血活血治疗不仅能明显改善症状和体征，而且实验室指标也得到改善，其疗效优于泼尼松.

Clinical effects of Yi-Qi-Jian-Pi therapy on sjogren's syndrome

AIM To observe the efficacy of Yi-Qi-Jian-Pi(YQJP) therapy on sjogren's syndrome(SS).METHODS Forty SS patients were enrolled.The patients were then randomly assigned into 2 groups:the treatment group(n=20) treated with oral Chinese medicine based on YQJP therapy(Huangqi,Taizishen,Baizhu,Beishashen,Maidong,Wuweizi,Baishao,Gancao,Wumei,Danshen,Jixueteng) and the control group treated with prednisone.RESULTS In the treatment group,the scores of sugar-melting test,saliva-secreting test and Schirmer's test were all significantly decreased as compared with that of before treatment(P<0.05).Moreover,the scores of Chinese medicine syndrome in the treatment group were also significantly decreased by the YQJP treatment as compared with that before treatment(P<0.01).On the other hand,the scores of Chinese medicine syndrome in the treatment group were significantly deceased as compared with the control group(P<0.05).Whereas the results of laboratory tests were significantly improved in both the treatment and control groups(P<0.05).The rate of improvement in Chinese medicine syndrome scores were 85% abd 55% in the treatnebt group and control group,respectively.However,there was no statistical difference in the improvement rates between these 2 groups.Total therapeutic effect was 80% and 55% in the treatment and control group,respectively.However,there was no statistical difference in total therapeutic effect between these 2 groups.CONCLUSION The YQJP therapy combined with Zi-Yin-Run-Zao and Yang-Xue-Huo-Xue is effective in reducing symptoms and physical signs as well improving the laboratory test parameters.The therapeutic effect of YQJP is superior than that of prednisone treatment.