培氟沙星与锌配合物的制备与抗菌活性测定

目的 制备培氟沙星与锌配合物,并观察其抗菌活性. 方法 氯化锌0.136 3 g和培氟沙星0.666 0 g化学反应制备配合物.对配合物进行元素分析和红外光谱分析,并进行体外抗菌活性测定. 结果 配合物各元素的组成比例为：锌(Zn) 13.16%,碳(C) 41.05%, 氢(H)4.02%, 氮(N)8.43%, 氯(Cl) 7.15%, 水(H2O )12.50%. 由元素分析可推知配合物的分子式为Zn₂(C₁₇H₂0FN₃O₃)₂Cl₂(H₂O)₇.培氟沙星在1 713 cm^-1处出现的羧基上C=O伸缩振动吸收峰,在配合物中消失,而在1 572.1,1 343.7 cm^-1则出现了对应于羧基的不对称和对称伸缩振动吸收峰,培氟沙星在1 634 cm^-1出现的萘啶环上羰基(C=O)伸缩振动吸收峰,在配合物中则红移了13个波数至1 621.2 cm^-1.培氟沙星对流感嗜血杆菌和粪链球菌的最低抑菌浓度分别为1.25和2.5 mg•mL^-1,配合物对流感嗜血杆菌、粪链球菌最低抑菌浓度分别为0.62和1.25 mg•mL^-1. 结论 该配合物制备方法简单,体外抗菌活性 结果表明, 培氟沙星与锌配合物对流感嗜血杆菌、粪链球菌的抑制作用略高于培氟沙星.

Preparation and Antibacterial Activity of the New Complex of Zn and Pefloxacin

Objective To prepare the complex of pefloxacin and zinc,and investigate its antimicrobial activity. Methods The complex was produced by chemical reaction between 0.136 3 g zinc chloride and 0.666 0 g pefloxacin.The elemental analysis and infrared spectroscopy were conducted for the complex detection,and the antibacterial activity was determined in vitro. Results The complex contained 13.16% Zn,41.05% C,4.02% H,8.43% N,7.15% Cl and 12.50% H2O.The molecular formula of the complex was extrapolated to be Zn2(C1...