| 复凝聚法制备桃金娘油肠溶微囊 |
| |
| 引用本文： | 蔡翠芳,曾雪萍,何海冰,齐 娜,唐 星. 复凝聚法制备桃金娘油肠溶微囊[J]. 沈阳药科大学学报, 2011, 28(7): 505-511 |
| |
| 作者姓名： | 蔡翠芳 曾雪萍 何海冰 齐 娜 唐 星 |
| |
| 作者单位： | （沈阳药科大学 药学院， 辽宁 沈阳 110016） |
| |
| 摘 要： | 目的采用复凝聚法制备桃金娘油肠溶微囊,并对其体外性质进行评价。方法选用海藻酸钠、氯化钙、壳聚糖为囊材采用复凝聚法制备桃金娘油微囊,用扫描电子显微镜(scanning electron microscope,SEM),Beckman Coulter LS 230激光粒度仪表征了微囊表面形态及粒径,采用顶空进样-GC色谱法测定了载药量和包封率。结果正交设计优化处方和工艺如下:海藻酸钠质量浓度为25g.L-1、壳聚糖质量浓度为3 g.L-1、凝聚速度为5 mL.min-1和凝聚时间为60 min,所得微囊粒径为(14.23±1.45)μm,载药质量分数为(11.3±0.4)%,包封率为(73.6±2.5)%。微囊具有耐酸和肠溶性能,表面褶皱,粒径分布均匀。结论复凝聚法可用于桃金娘油肠溶微囊的制备。
|
| 关 键 词： | 桃金娘油 肠溶微囊 复凝聚法 |
| 收稿时间： | 2010-10-08 |
Enteric myrtle oil microcapsules by complex coacervation |
| |
| CAI Cui-fang,ZENG Xue-ping,HE Hai-bing,Qi Na,TANG Xing. Enteric myrtle oil microcapsules by complex coacervation[J]. Journal of Shenyang Pharmaceutical University, 2011, 28(7): 505-511 |
| |
| Authors: | CAI Cui-fang ZENG Xue-ping HE Hai-bing Qi Na TANG Xing |
| |
| Affiliation: | (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China) |
| |
| Abstract: | Objective To prepare myrtle oil enteric-coated microcapsules using a complex coacervation method and evaluate the in vitro performance.Methods Sodium alginate,calcium chloride and chitosan were selected as the materials for myrtle oil loaded microcapsules;surface morphology and size of microcapsules were characterized by scanning electronic microscopy(SEM)and laser diffraction particle size analyzer(Beckman Coulter LS 230).The headspace gas chromatography(HS-GC)method was employed to determine the loading c... |
| |
| Keywords: | myrtle oil enteric microcapsule complex coacervation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《沈阳药科大学学报》浏览原始摘要信息 |
|
点击此处可从《沈阳药科大学学报》下载全文 |
|
