| SOCS-1、SOCS-3、TNF-a在有机磷中毒鼠肝脾的表达 |
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| 引用本文： | 欧阳艳红,李松玲,宋维,赵宁,马中富. SOCS-1、SOCS-3、TNF-a在有机磷中毒鼠肝脾的表达[J]. 中国热带医学, 2009, 9(1) |
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| 作者姓名： | 欧阳艳红 李松玲 宋维 赵宁 马中富 |
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| 作者单位： | 1. 海南省人民医院急救中心,海南海口,570102
2. 中山大学附属第一医院普内科,广东广州,510080 |
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| 基金项目： | 2007海南省自然科学基金(30718) |
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| 摘 要： | 目的观察有机磷中毒(AOPP)小鼠肝脏、脾脏SOCS-1、SOCS-3及TNF-amRNA的表达,探讨其在AOPP致多器官功能障碍综合症(MODS)中的发病机制,以期为MODS的防治提供新的策略。方法健康小鼠随机分成敌敌畏组、生理盐水对照组和正常对照组,分别于染毒后2、6、12、24h取肝脾组织,以逆转录聚合酶链反应(RT-PCR)测定SOCS-1、SOCS-3、TNF-a表达水平。结果AOPP小鼠肝脾SOCS-1、SOCS-3、TNF-a表达均升高,与对照组比较差异有统计学意义(P均<0.05)。结论AOPP可导致细胞因子TNF-a失调,可能参与了AOPP后SIRS向MODS的发病过程;若能抑制炎症反应的失控,则对中毒MODS的治疗将有新的突破。
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| 关 键 词： | SOCS-1 SOCS-3 TNF-a 有机磷农药中毒 MODS |
Study on the expression of SOCS-1 and SOCS-3, TNF-a in liver and spleen of multiple organ dysfunction syndrome mice induced by acute organophosphorus pesticide poisoning |
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| OUYANG Yan - hong,LI Song -ling,SONGWei,et al.. Study on the expression of SOCS-1 and SOCS-3, TNF-a in liver and spleen of multiple organ dysfunction syndrome mice induced by acute organophosphorus pesticide poisoning[J]. China Tropical Medicine, 2009, 9(1) |
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| Authors: | OUYANG Yan - hong LI Song -ling SONGWei et al. |
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| Abstract: | Objective To investigate the dynamic of SOCS-1.SOCS -3 TNF-a in live and spleen of MODS mice induced by acute organophosphorus pesticide poisoning (AOPP),and discuss the mechanism of MODS induced by AOPP. Methods The mice were randomly:divided into AOPP group. And control group .and the liver and the spleen tissue were taken in 2 hours ,6 hours ,12 hours and ,24 hours after exposed to poison for pathological test as well as RNA and protein.The expression of regulatory genes SOCS-1 .SOCS- 3 and TNF-a were de... |
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| Keywords: | SOCS-1 SOCS-3 TNF-a AOPP MODS |
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