微创术对脑出血后脑水肿患者血浆明胶酶B的影响

目的探讨高血压性脑出血微创术对清除血肿后脑水肿患者血浆明胶酶B(MMP-9)的影响。方法127例脑出血患者随即分为内科治疗组60例、微创术血肿抽吸引流组67例;采用酶联免疫法(ELISA)测定脑出血后第3天、第7天和第21天血浆MMP-9含量。结果微创组和内科治疗组血浆中MMP-9含量均升高;两组治疗后第3、7天的含量与治疗前(发病24h内)比较,差异有统计学意义(P<0.05);两组治疗后不同时间点血浆中MMP-9含量比较,差异有统计学意义(P<0.05)。结论微创组能减少患者血浆MMP-9含量的增加。

Effect of hematoma aspiration on the development of cerebral edema and MMP-9 in the patients of intracerebral hemorrhage

Objective To investigate the dynamic changes of cerebral edema and MMP-9 after hematoma aspiration in the patients of intracerebral hemorrhage (ICH). Methods The plasma was obtained from 127 patients who were assigned randomly into control group and treatment group (hematoma aspiration after ICH). Before treatment, and at 3rd, 7th, 21st day after the treatment, the MMP-9 levels of plasma were detected by ELISA. Results The MMP-9 levels increased in both control group and treatment group, and MMP-9 levels at 3rd and 7th day after the treatment were all significantly higher than those before the treatment in two groups(P<0.05).The increased levels were fewer in treatment group than in control group at 3rd and 7th day after the treatment . There were statistical differences in MMP-9 levels at different time points after the treatment in two groups(P<0.05). Conclusion Hematoma aspiration can decrease the increase of MMP-9.