氯沙坦对伴有微量蛋白尿的老年高血压患者的影响

目的　观察氯沙坦对伴有微量蛋白尿（ ＭＣＡ） 的老年高血压患者改善肾损害的作用。　方法　采用连续样本，自身前后及分组对照方法，对３２ 例高血压伴ＭＣＡ 者（ＥＨ 组） ，男２４ 例，女８ 例，平均年龄（７１－６ ±６－８）岁，观察在治疗前和每天服用氯沙坦５０ ｍ ｇ １２ 周后的血压、血尿素氮（ＢＵＮ） 、血肌酐（Ｃｒ） 、２４ｈ 内生肌酐清除率（Ｃｃｒ） 、尿白蛋白／ 肌酐（Ａｌｂ／Ｃｒ） 的变化，ＥＨ 组治疗前在ＢＵＮ、Ｃｒ 、Ｃｃｒ 方面与１２ 例非高血压老人作对照（ 对照组） 。　结果　治疗前ＥＨ 组的Ｃｃｒ 水平较对照组明显降低（ Ｐ＜ ０－０５） ，用氯沙坦治疗后，除血压有明显下降外，尿Ａｌｂ／Ｃｒ 亦显著性降低（ Ｐ＜ ０－０１） ，Ｃｃｒ 明显升高（ Ｐ＜ ０－０５） 。　结论　氯沙坦对老年高血压患者不仅有良好的降压效果，同时可降低尿白蛋白的排泄，改善肾功能

Effect of losartan in elderly essential hypertensive patients with microalbuminuria

To study the effect of losartan in elderly essential hypertensive patients with microalbuminuria(MCA). Methods Before after study was performed in 32 consecutive samples of elderly essential hypertensive patients with MCA(EH group).The blood pressure,creatinine clearance rate(Ccr),urea nitrogen(BUN),serum creatinine(Cr)and urinary albuminindex(Alb/Cr)were messured before and after losartan 50mg per day treatment for 12 weeks.Ccr,BUN and Cr in EH group were compared to those of 12 normotensive subjects(control group). Results Ccr in EH group was significantly lower than that of in control group ( P <0 05).Besides blood pressure,Alb/Cr was significantly reduced( P <0 01)and Ccr was markedly increased( P <0 05)after losartan treatment. Conclusions Losartan can effectively decrease blood pressure,urinary protein excretion and improve renal function in elderly essential hypertensive patients with MCA.