Simple fibroblast-based assay to test the pyrazinamide susceptibility of Mycobacterium tuberculosis |
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| Authors: | Takii Takemasa Hamasaki Sonomi Hirano Kazue Abe Chiyoji Onozaki Kikuo |
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| Affiliation: | Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-Ku, Nagoya 467-8603, Japan. ttakii@phar.nagoya-cu.ac.jp |
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| Abstract: | A simple fibroblast-based assay (SFA) was found to be efficient in evaluating the susceptibilities of clinical isolates of Mycobacterium tuberculosis to pyrazinamide (PZA). Forty-five clinical isolates were examined. The MICs of PZA for susceptible strains in an SFA were between 3.13 and 12.5 microg/ml, and the MICs of PZA for resistant strains were more than 100 microg/ml. |
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