| 肾炎康复片对大鼠肾间质纤维化的保护作用 |
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| 引用本文： | 叶婷婷,沈建明,邓妍妍,王黎萍,田林,田少江,李骏峰,刁路明.肾炎康复片对大鼠肾间质纤维化的保护作用[J].郧阳医学院学报,2008,27(5). |
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| 作者姓名： | 叶婷婷 沈建明 邓妍妍 王黎萍 田林 田少江 李骏峰 刁路明 |
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| 作者单位： | [1]武汉大学医学院病理学教研室,湖北武汉430071 [2]郧阳医学院附属人民医院肾内科,湖北十堰442000 [3]郧阳医学院附属人民医院病理科,湖北十堰442000 |
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| 摘 要： | 目的:研究肾炎康复片对单侧输尿管梗阻(UUO)大鼠肾间质纤维化的保护作用。方法:21只SD大鼠随机分为假手术组(Sham组)、肾间质纤维化组(UUO组)及肾炎康复片组(SKT组),观察大鼠UUO术后14d梗阻侧肾脏的组织学变化、纤维连接蛋白(FN)及基质金属蛋白酶抑制物-1(TIMP-l)的表达情况。结果:与Sham组相比,UUO组大鼠肾间质纤维化面积显著增加(P<0.01),FN及TIMP-1表达均有显著增高(P<0.01);与UUO组相比,SKT组大鼠肾间质纤维组织面积减少,FN及TIMP-1表达减弱(P<0.01);UUO组和SKT组大鼠FN及TIMP-1与肾间质纤维化面积成正相关(P<0.01)。结果:肾炎康复片可下调FN和TIMP-1在UUO大鼠肾间质中的表达,从而延缓肾间质纤维化的进展。
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| 关 键 词： | 肾炎康复片 肾间质纤维化 纤维连接蛋白 基质金属蛋白酶抑制物-1 |
Protective Effect of Shenyankangfu Tablet on Renal Interstitial Fibrosis in Rats |
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| YE Ting-ting,SHEN Jian-ming,DENG Yan-yan,WANG Li-ping,TIAN Ling,TIAN Shao-jiang,LI Jun-feng,DIAO Lu-ming.Protective Effect of Shenyankangfu Tablet on Renal Interstitial Fibrosis in Rats[J].Journal of Yunyang Medical College,2008,27(5). |
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| Authors: | YE Ting-ting SHEN Jian-ming DENG Yan-yan WANG Li-ping TIAN Ling TIAN Shao-jiang LI Jun-feng DIAO Lu-ming |
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| Institution: | YE Ting-ting1,2,SHEN Jian-ming2,DENG Yan-yan2,WANG Li-ping2,TIAN Ling3,TIAN Shao-jiang2,LI Jun-feng2,DIAO Lu-ming1(1Department of Pathology,College of Medicine,Wuhan University,Wuhan,Hubei 430071,China,2Department of Nephorology,3Department of Pathology,Renmin Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To study the protective effects of Shenyankangfu tablet on renal interstitial fibrosis in rats with unilateral ureteral obstruction(UUO).Methods Twenty-one SD rats were randomly divided into 3 groups,sham group,UUO group and Shenyankangfu tablet group(SKT group).Renal pathology was analyzed with HE and Masson staining,and immunohistochemistry staining was employed to study the expression of fibronectin and tissue inhibitor of metalloproteinases-1(TIMP-1).Results Compared with sham group,the area o... |
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| Keywords: | Shenyankangfu tablet Renal interstitial fibrosis Fibronectin Tissue inhibitor of metalloproteinases-1 |
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