Comparative genome maps of the pangolin, hedgehog, sloth, anteater and human revealed by cross-species chromosome painting: further insight into the ancestral karyotype and genome evolution of eutherian mammals |
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Authors: | Fengtang Yang Alexander S Graphodatsky Tangliang Li Beiyuan Fu Gauthier Dobigny Jinghuan Wang Polina L Perelman Natalya A Serdukova Weiting Su Patricia CM O'Brien Yingxiang Wang Malcolm A Ferguson-Smith Vitaly Volobouev Wenhui Nie |
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Institution: | (1) Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China;(2) Institute of Cytology and Genetics, SB RAS, Novosibirsk, 630090, Russia;(3) Centre for Veterinary Sciences, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK;(4) Institut de Recherche pour le Développement, Centre de Biologie et Gestion des Populations, Campus International de Baillarguet, CS30016, 34988 Montferrier-sur-Lez, France;(5) Muséum National d'Histoire Naturelle, Origine, Structure et Evolution de la Biodiversité, 55, rue Buffon, 75005 Paris, France;(6) Present address: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK |
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Abstract: | To better understand the evolution of genome organization of eutherian mammals, comparative maps based on chromosome painting
have been constructed between human and representative species of three eutherian orders: Xenarthra, Pholidota, and Eulipotyphla,
as well as between representative species of the Carnivora and Pholidota. These maps demonstrate the conservation of such
syntenic segment associations as HSA3/21, 4/8, 7/16, 12/22, 14/15 and 16/19 in Eulipotyphla, Pholidota and Xenarthra and thus
further consolidate the notion that they form part of the ancestral karyotype of the eutherian mammals. Our study has revealed
many potential ancestral syntenic associations of human chromosomal segments that serve to link the families as well as orders
within the major superordinial eutherian clades defined by molecular markers. The HSA2/8 and 7/10 associations could be the
cytogenetic signatures that unite the Xenarthrans, while the HSA1/19p could be a putative signature that links the Afrotheria
and Xenarthra. But caution is required in the interpretation of apparently shared syntenic associations as detailed analyses
also show examples of apparent convergent evolution that differ in breakpoints and extent of the involved segments. |
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Keywords: | ancestral karyotype Carnivora chromosome painting Eulipotyphla Pholidota Xenarthra |
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