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长春西汀治疗高血压伴脑动脉硬化和脑血栓形成后遗症
引用本文:杨学义 ,韩宝福 ,杨英珍 ,陈灏珠 ,梁子钧,林镇海.长春西汀治疗高血压伴脑动脉硬化和脑血栓形成后遗症[J].中国新药与临床杂志,1989(3).
作者姓名:杨学义  韩宝福  杨英珍  陈灏珠  梁子钧  林镇海
作者单位:上海医科大学生物物理教研组,上海医科大学生物物理教研组,上海医科大学附属中山医院,上海市心血管病研究所 上海 200032
摘    要:本文报道长春西汀5mg,tid,治疗高血压伴脑动脉硬化和脑血栓形成后遗症患者3O例,4wk为一疗程。自觉症状总有效率为93%,显效率为25%;精神症状总有效率为84%,显效为11%;神经症状总有效率为96%,显效为22%。血液粘度明显降低,血小板聚集率及纤维蛋白原下降。并能选择性增加脑缺血部位的血供,改善脑循环和代谢,保护缺血脑组织。无明显不良反应。

关 键 词:长春西汀  脑栓塞和血栓形成  流变学

Effect of vinpocetine on hypertensive patients with cerebral arteriosclerosis and cerebral thrombosis
YANG Xue-Yi,HAN Bao-Fu,YANG Ying-Zhen,CHEN Hao-Zhu,LIANG Zi-Jun,LIN Zhen-Hai.Effect of vinpocetine on hypertensive patients with cerebral arteriosclerosis and cerebral thrombosis[J].Chinese Journal of New Drugs and Clinical Remedies,1989(3).
Authors:YANG Xue-Yi  HAN Bao-Fu  YANG Ying-Zhen  CHEN Hao-Zhu  LIANG Zi-Jun  LIN Zhen-Hai
Abstract:The effect of vinpocetine on 30 hypertensive patients with cerebral arteriosclerosis and cerebral thrombosis was studied.The drug was administered in dosage of 5 mg tid for 4 wesks.The subjective symptoms were improved in 93% and markedly improved in 25% of patients; psychic symptoms were improved in 84% and markedly improved in 11% of patients; neurologic symptoms were improved in 96% and markedly improved in 22%.The blood viscosity were improved,lowering down of plasma platelet-aggregative ratio and fibrinogen level. Vinpocetine properly increased the blood supply in the cerebral circulation, improved the cerebral ischemic condition and protected the brain tissues.The adverse effects were seldom.
Keywords:vinpocetine  cerebral embolism and thrombosis  rheology  
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