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Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer |
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| Authors: | Capo-chichi Callinice D Cai Kathy Q Smedberg Jennifer Ganjei-Azar Parvin Godwin Andrew K Xu Xiang-Xi |
| Affiliation: | Callinice D.Capo-chichi1,2,Kathy Q.Cai3,Jennifer Smedberg3,Parvin Ganjei-Azar1,4,Andrew K.Godwin5 and Xiang-Xi Xu1,6 1Sylvester Comprehensive Cancer Center,2Department of Medicine,4Department of Pathology,and 6Department of Obstetrics and Gynecology,University of Miami School of Medicine,Miami,FL 33136,USA,3Ovarian Cancer Program,Fox Chase Cancer Center,Philadelphia,PA 19111,5Department of Pathology and Laboratory Medicine,University of Kansas Medical Center,Kansas City,KS 66160,USA. |
| Abstract: | Through advances in technology,the genetic basis of cancer has been investigated at the genomic level,and many fundamental questions have begun to be addressed.Among several key unresolved questions in cancer biology,the molecular basis for the link between nuclear deformation and malignancy has not been determined.Another hallmark of human cancer is aneuploidy;however,the causes and consequences of aneuploidy are unanswered and are hotly contested topics.We found that nuclear lamina proteins lamin A/C are ... |
| Keywords: | Nuclear envelope lamin A/C aneuploidy polyploidy nuclear grade nuclear morphology breast cancer |
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