Mouse models of medulloblastoma |
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| Authors: | Wu Xiaochong Northcott Paul A Croul Sidney Taylor Michael D |
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| Affiliation: | Xiaochong Wu,Paul A. Northcott,Sidney Croul and Michael D. Taylor Arthur and Sonia Labatt Brain Tumor Research Center,Hospital for Sick Children,Toronto,Ontario,M5G 1L7,Canada |
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| Abstract: | Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve a valuable role as preclinical models for testing targeted therapies. In this review, we summarize how such models... |
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| Keywords: | Genetically engineered mouse medulloblastoma mouse model |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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