Role of microglia in neuronal degeneration and regeneration |
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| Authors: | Lisa Walter and Harald Neumann |
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| Affiliation: | (1) Department of Pharmacology, University of Cologne, Gleueler Str. 24, 50931 Cologne, Germany;(2) Institute of Reconstructive Neurobiology, University Hospital Bonn, University Bonn and Hertie-Foundation, Sigmund-Freud Str. 25, 53127 Bonn, Germany; |
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| Abstract: | Microglial cells, the resident macrophage population of the central nervous system (CNS), actively scan tissue under both normal and pathologic contexts. Their resulting engagement can become either neuroprotective or neurotoxic, leading to amelioration or aggravation of disease progression. In this review, we focus on the molecular signaling molecules involved in microglial responses and discuss observations demonstrating the diverse effects of microglia in animal models of CNS diseases. |
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