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Mouse models for cancer research
Authors:Zhang Wei  Moore Lynette  Ji Ping
Affiliation:Wei Zhang,Lynette Moore,and Ping Ji Department of Pathology,The University of Texas M.D. Anderson Cancer Center,Houston,Texas 77030,USA.
Abstract:Mouse models of cancer enable researchers to learn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Journal of Cancer will publish a series of papers reporting the use of mouse models in studying genetic events in cancer cases. This editorial is an overview of the de...
Keywords:Knockout mouse  gene targeting  stem cells  oncogene  tumor suppressor gene  
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