Pharmacokinetics of 8-methoxypsoralen in serum and suction blister fluid |
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Authors: | Jorma Lauharanta Timo Juvakoski Lasse Kanerva Allan Lassus |
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Affiliation: | (1) Department of Dermatology, University Central Hospital, Snellmaninkatu, 14, SF-00170 Helsinki 17, Finland |
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Abstract: | Summary Micronized 8-methoxypsoralen (8-MOP), with a smaller crystal size, produced significantly higher serum level profiles than nonmicronized 8-MOP. Furthermore, the absorption of the micronized drug was more rapid, resulting in peak serum levels within 1 h in 75% of the patients. Our blister fluid studies suggest, however, that reduction of the photosensitizer concentration is slower in skin than in serum. This implies that despite markedly reduced 8-MOP serum level after 2 h the skin remains sufficiently sensitized up to that point of time. |
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Keywords: | Micronized and nonmicronized 8-methoxypsoralen PUVA Suction blister |
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