晕痣和痣细胞痣bcl-2蛋白的表达

为了研究细胞凋亡在晕痣发生中的作用,我们对8例晕痣和8例痣细胞痣患者皮损进行了bcl-2原癌基因产物(B-cell lymphoma/leukemia 2 gene product,以下简称bcl-2)的免疫组化观察.结果表明8例晕痣均见有bcl-2的阳性表达,8例痣细胞痣仅有3例表达bcl-2,而且染色明显较弱,大部分组织呈阴性表达.由于两种痣bcl-2表达明显不同,作者认为晕痣组织内bcl-2的过量表达与晕痣发生的自身免疫机制有关,可能是痣组织内对痣细胞的高凋亡率的一种自动平衡反应.

Expression of bcl 2 in Tissues from Halo Nevus and Melanocytic Nevus

In order to study the role of apoptosis on halo nevus development, we studied the expression of bcl 2 in 8 patients with halo nevus and 8 patients with melanocytic nevus using immunohistochemical methods. All 8 patients with halo nevus and 3 of 8 patients with melanocytic nevus expresed bcl 2, but the staining was significantly weaker in the patients with melanocytic nevus. Because the expression of bcl 2 was obviously different in the tissues of the two types of nevus, the authors believe that the over expression for bcl 2 may be related to the autoimmune mechanism of halo nevus development, and it may be a homeostatic response to high rate of apoptosis in the tissues of halo nevus.