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| 大鼠局灶性脑缺血模型及其与C反应蛋白变化的关系 | |
| 引用本文： | 林春,郑淑秋,钟觉民,颜光美. 大鼠局灶性脑缺血模型及其与C反应蛋白变化的关系[J]. 福建医科大学学报, 1999, 33(3): 251-255 |
| 作者姓名： | 林春 郑淑秋 钟觉民 颜光美 |
| 作者单位： | 1. 福建医科大学生理学教研室,福州,350004 2. 中山医科大学病理学教研室,广州,510080 3. 中山医科大学药理学教研室,广州,510080 |
| 基金项目： | 国家杰出青年基金! (3 962 5 0 2 2 )，美国中华医学基金会基金 !(93 - 5 94 ) |
| 摘 要： | 目的 改进大鼠大脑中动脉梗塞法，建立更接近于临床缺血性脑卒中及其再扩灌注的可靠模型，并观察其与血甭Ｃ反应蛋白变化的。方法沿大鼠右颈内动脉插入长２．１￣２．３ｃｍ直径０．２０５ｍｍ的单股尼龙丝，直达大脑中动脉起始部开口，阻断其血流，观察大鼠神经病学改变及脑组织形态学变化，并测定血清Ｃ反应蛋白含量。结果 术后大鼠表现特殊体态及典型追尾征，６ｈ大脑中动脉供血区出现缺血性外观（ＴＴＣ染色）及相应组织学变化 |
| 关 键 词： | 大脑中动脉梗塞 缺血性脑卒中 C反应蛋白 大鼠 |
A Model of Regional Cerebral Ischemia and its Relationship with C-reactive Protein Change |
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| Lin Chun+,Zheng Shuqiu+,Zhong Juemin+,et al. A Model of Regional Cerebral Ischemia and its Relationship with C-reactive Protein Change[J]. Journal of Fujian Medical University, 1999, 33(3): 251-255 | |
| Authors: | Lin Chun+ Zheng Shuqiu+ Zhong Juemin+ et al |
| Affiliation: | Lin Chun+1,Zheng Shuqiu+2,Zhong Juemin+3,et al |
| Abstract: | An ideal animal model of middle cerebral artery occlusion(MCAO) was developed and the relationship between the model and C reactive protein change was investigated Methods A fine and glossy nylon suture was introduced into the right cervical internal carotid artery and advanced intracranially to block blood flow into the MCA,changes of neurological syndromes and of morphology of brain were observed and CRP of serum was measured in rats Results After MCAO,special neurological syndromes were showed by rats, the infarct surface in the area of MCA(TTC coloring, after MCAO 6 h) and corresponding change of brain histology(HE staining) were appeared and success rate of the model reached 95%(71/75); meanwhile CRP of serum rose(15 9%, P<0 05) Conclusion A reversible model of regional cerebral ischemia in rats was developed,the reliability of which could be evaluated by neurological syndromes, morphologic change and rise of serum CRP |
| Keywords: | middle cerebral artery occlusion ischemic stroke C-reactive protein rat |
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