在不同牙周出血状态下唾液乙肝病毒浓度的比较研究

目的：研究不同牙周出血状态下唾液中的乙肝病毒浓度，探讨乙型肝炎经唾液传染的可能性。方法：用荧光定量PCR法对不同牙周出血情况下的乙肝患者血清和唾液分别进行HBV DNA定量分析。结果：唾液中均可榆出乙肝病毒，在末被血液污染的唾液中，病毒浓度与其血液浓度呈正相关关系(回归方程为：Y=1．105x-3.877)，被血液不同程度污染的唾液与未被血液污染的唾液中乙肝病毒浓度没有明显差异(P＞0.05)。结论：血清中乙肝病毒浓度高的患者，其未被血液污染的唾液(口腔无出血情况)仍有较高传染性。

Quantitative detection of HBV DNA in saliva of serological HBV DNA positive patients in different intraoral clinical conditions

AIM:To detect the concentration of HBV DNA in saliva of patients in different intraoral clinical conditions and to determine the epidemiology.METHODS:The HBV DNA concentrations in saliva and in blood were tested respectively by fluorescent quantitative PCR (FQ-PCR).RESULTS:The concentrations of HBV DNA were no significant difference among heavy-blood-contaminated saliva,moderate-blood-contaminated saliva and non-contaminated saliva( P >0.05).There was a correlation between the concentration of HBV DNA in serum and that in non-blood-contaminated saliva(linear regression equation:Y=1.105X-3.877).CONCLUSIONS:Patients with higher HBV DNA concentration in serum,their non-contaminated saliva is still rather high contagious.