东莨菪碱诱发染色体畸变的剂量效应

东茛菪碱五个剂量(1、2、5、10、20μg/ml作用于12名健康成人外周血淋巴细胞培养液诱发染色体畸变,并设空白对照组(生理盐水)。染色体畸变率分别为3.±0.5,9.6±1.1,11.7±1.1,13.6±2.3,18.0±3.0和17.5±2.0％;细胞畸变率为3.1±0.6,9.2±0.6,10.0±0.8,10.8±1.5,11.6±1.8和12.2±14.％。各剂量组与对照组比较差异高度显著(P<0.01)。方差分析,各剂量组间变异的差异高度显著(P<0.01)。相关系数和回归系数也非常显著(P<0.01)。结果表明,东莨菪碱剂量与染色体畸变率和细胞畸变率有线性关系。

Dose-Recponse of Chromosomal Aberration Induced by scopoiamins

The effect of 1,2,5,10,and 20μg of scopolamine in per ml culture of peripheral blood lymphocyte chromosome from 12 heaithy adults was studied for thromosome aberration rate and cell aberration rate. A group without scopolamine served as control. The rates of chromosome aberration were 3.5±0.5, 9.6±1.1, 11.7±1.1, 13.6±2.3,18.0±+3.0, and 17.5±2.0%, those of cell aberration was 3.1±0.6, 9.2±0.6, 10.0±0.8, 10.8±1.5, 11.6±1.8 and 12.2±1.4% respectively. The difference was remarkably great(P<0.01) between each study group and its contol group. By anlysis of variance, there was also a highly significant difference between the study groups (P<0.01). Both correlation coeffecient and regression coefficient were highly remarkable (P<0.01). The results showed the linearity relation between the dose of scpolamine and the chromsome aberration and cell aberration rate induced by it.